I love Metroid Prime Hunters, though I still suffer from painful hand-cramping after a playing for any length of time. It looks like I'm not the only one, on both counts:

While Nintendo's use of the touch screen in DS games typically feels like innovation, this time the need to hold a stylus while playing a fast-paced shooter feels more like making the best of a bad situation.
Fortunately, the game's pacing, intriguing action single-player mode and competitive multiplayer mode outweigh the bad in Metroid Prime Hunters. The end result is a game you'll want to return to again and again.
Score: B
Rocky Mountain News

Metroid Prime: Hunters is an excellent multiplayer game and easy to recommend to anyone who enjoys FPS action. The single-player is also well worth a play through, despite its limitations, if only to take in the story and unlock all the hunters for multiplayer action.
Score: 86 percent
GameSpot

This is the first truly playable first-person shooter for a portable system. The technology of the DS has seemed like a crutch for the scant few FPS titles on it, but Hunters utilizes the console's capabilities to the fullest.
Score: 5 of 5
Yahoo Games

Despite some shortcomings, Hunters is a fabulous game that DS owners should pick up and enjoy, especially if they have the means to hop online.
Score: 90 percent
eToychest

Metroid Prime Hunters is easily the best handheld first person shooter developed to date, even with its somewhat high learning curve and cramp-inducing control.
Score: 9/10
IGN